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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
27.88
Human Site:
Y108
Identified Species:
43.81
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
Y108
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
Y103
V
D
Q
D
L
R
T
Y
L
D
K
A
P
P
P
Dog
Lupus familis
XP_852360
326
36788
Y108
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
Y108
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
Rat
Rattus norvegicus
P35426
303
33780
Y103
I
D
Q
D
L
R
T
Y
L
D
K
A
P
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
L9
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
Chicken
Gallus gallus
P13863
303
34670
T93
D
L
K
K
Y
L
D
T
I
P
S
G
Q
Y
L
Frog
Xenopus laevis
Q91727
319
35666
Y103
V
D
Q
D
L
K
T
Y
L
S
K
V
P
P
P
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
Y105
V
D
Q
D
L
T
T
Y
L
E
K
A
P
D
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
L120
V
E
Q
D
L
S
D
L
I
D
R
L
P
K
S
Honey Bee
Apis mellifera
XP_391955
457
50351
L248
D
R
G
L
T
L
W
L
V
F
E
H
V
E
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
Q108
L
V
D
Q
D
L
A
Q
Y
L
E
K
C
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
P95
K
K
F
M
D
S
C
P
E
F
A
K
N
P
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
P95
K
K
H
M
D
S
T
P
D
F
S
K
D
L
H
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
Y98
L
D
L
D
L
K
R
Y
M
E
G
I
P
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
80
100
N.A.
100
73.3
N.A.
13.3
0
80
80
N.A.
40
6.6
N.A.
6.6
P-Site Similarity:
100
N.A.
80
100
N.A.
100
80
N.A.
20
13.3
80
93.3
N.A.
80
20
N.A.
20
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
33.3
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
13.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
0
0
7
20
0
0
0
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% C
% Asp:
14
54
7
60
20
0
14
0
14
40
0
0
7
7
7
% D
% Glu:
0
7
0
0
0
0
0
0
7
14
14
0
0
27
0
% E
% Phe:
0
7
7
0
0
0
0
0
0
27
0
0
0
0
0
% F
% Gly:
0
0
7
0
0
0
7
0
0
0
7
7
0
0
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
14
0
7
7
% H
% Ile:
7
0
0
0
0
0
0
0
14
0
0
7
0
0
0
% I
% Lys:
14
14
7
7
0
14
0
0
0
0
47
20
0
14
0
% K
% Leu:
14
7
7
14
67
20
0
20
47
7
7
7
0
7
7
% L
% Met:
7
0
0
14
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
14
0
7
0
0
60
34
54
% P
% Gln:
0
0
60
7
0
0
0
7
0
0
0
0
7
0
0
% Q
% Arg:
0
7
0
0
0
20
7
0
0
0
7
0
0
0
14
% R
% Ser:
0
0
0
0
0
20
0
0
0
7
14
0
7
0
7
% S
% Thr:
0
0
0
0
7
27
54
7
0
0
0
0
0
0
7
% T
% Val:
47
7
0
0
0
0
0
0
7
0
0
27
7
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
54
7
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _